Showing posts with label treatment. Show all posts
Showing posts with label treatment. Show all posts

Saturday, 28 December 2019

Exercise reported to improve erectile dysfunction


When Viagra first appeared on the market, many men with erectile dysfunction found that it could lead back in the pencil. However, Viagra and other drugs for erectile dysfunction are expensive and associated with side-effects such as headache and nasal congestion. Now, a new study has found that exercise can improve erectile dysfunction. The study was published in the March edition of The Journal of Sexual Medicine by researchers at Duke University School of Medicine (Durham, NC) and Cedars-Sinai Medical Center (Los Angeles, CA).
Exercises to Eliminate Erectile Dysfunction

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The study group comprised 295 men. Their average age was 62 years, and they were all overweight or obese. Approximately one third had diabetes or a history of chest pain or heart attacks. About 75% were current or former smokers. A significant proportion (93) were African-American. The aim of the study was to assess whether exercise is associated with better erectile as well as sexual function in black men and define a minimum exercise level for which better erectile/sexual function could occur.

The men were participants in a study that assessed risk factors for prostate cancer; the study was conducted at the Durham Veterans Affairs Medical Center. Exercise and erectile/sexual function were both evaluated by self-reported questionnaires. The men were divided into four exercise groups based on metabolic equivalents (MET) hours per week: less than 3 MET (sedentary);,3–8.9 (mildly active) MET; 9–17.9 (moderately active) MET; and more than 18 (highly active) MET. The relationship between exercise and erectile/sexual function was assessed via statistical analysis.

Erectile/sexual function was defined by the validated Expanded Prostate Cancer Index Composite sexual assessment, which yielded a sexual function score. Clinically significant better function was defined as half a standard deviation (SD) of 16.5 points.

The researchers found that the average sexual function score was 53 (SD = 33). Higher exercise was associated with a better sexual function score. Of significance, there was no interaction between black race and exercise, which meant that more exercise was associated with better erectile/sexual function regardless of race. Overall, exercise at 18 or more MET hours per week predicted better erectile/sexual function with a clinically significant (17.3-point) higher function. Exercise at lower levels was not statistically or clinically associated with erectile/sexual function.

The authors concluded that among a racially diverse population, exercise at a level of 18 or more MET hours per week is significantly associated with better erectile/sexual function regardless of race.
Erectile dysfunction may improve with exercise


New study rates, effectiveness, side-effects of erectile dysfunction drugs


A variety of erectile dysfunction drugs are available on the market; however, side-effects and effectiveness differ. A new study evaluated currently available erectile dysfunction drugs in this regard. The study was published in the April edition of the journal European Urology by researchers at the University of Zurich, the Swiss Federal Institute of Technology, and Maastricht University Medical Center in the Netherlands.
Some drugs can cause unwanted sexual side effects in men


The authors reviewed 82 studies of the drugs’ effectiveness and 72 studies that assessed side-effects. They compared seven common erectile dysfunction medications, which all belonged to a class of drugs known as phosphodiesterase 5 inhibitors (PDE5i’s). They work by inhibiting an enzyme that may reduce the potency of an erection. The investigators reviewed Viagra (sildenafil), Cialis (tadalafil), Levitra (vardenafil), and Stendra (avanafil). In addition, they evaluated Zydena (udenafil), Helleva (lodenafil), and Mvix (mirodenafil), which are only available in other countries.

The aforementioned drugs are considered the first-choice therapy for erectile dysfunction; however they are only effective for 60-80% of men. The authors note that all the medications are more effective than s placebo for treating erectile dysfunction, and are generally safe and well tolerated. A 50 or 100 milligram (mg) dose of Viagra was found to be the most effective treatment. It was approximately 50% better than a placebo. Lower doses were less effective. Stendra, in doses ranging from 50 to 200 mg, was one of the least effective drugs studied; it was only 20-30% more effective than a placebo.

In regard to side-effects, the 50 milligram dose of Stendra was reported to have the lowest rate of side effects among the drugs studied; only 8.5% of the subjects reported side-effects. A 20 mg dose of Levitra had the highest rate of side effects: 25%. Higher doses of Viagra and Cialis caused side effects 21-22% of the time.

One side-effect of erectile dysfunction drugs is that they are vasodilators (blood vessel dilators) that cause a drop in blood pressure. Thus, they are not recommended for men taking nitrate-based heart medications because they can cause a sharp drop in blood pressure. Other common side effects include facial flushing, sinus congestion, headache, and upset stomach. Cialis is the only medication that can be taken daily. It is also reported to reduce the symptoms of benign prostate hypertrophy (BPH; enlarged prostate). The other medications are only effective for a short period of time. Erectile dysfunction drugs require a prescription; thus, which drug to take should be thoroughly discussed with your physician.
Viagra, Cialis, Levitra, and Stendra


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